منابع مشابه
Age at onset and Parkinson disease phenotype.
OBJECTIVE To explore clinical phenotype and characteristics of Parkinson disease (PD) at different ages at onset in recently diagnosed patients with untreated PD. METHODS We have analyzed baseline data from the Parkinson's Progression Markers Initiative database. Four hundred twenty-two patients with a diagnosis of PD confirmed by DaTSCAN imaging were divided into 4 groups according to age at...
متن کاملAge at onset in Huntington's disease and methylation at D4S95.
Age at onset in Huntington's disease (HD) is variable and is influenced by parental sex, paternal age, and genetic background. Several recent models have tried to explain this variable expressivity by invoking parental imprinting and related aspects of epigenetic inheritance. Some of these mechanisms may result in variable DNA methylation at or near the HD gene. We show here that methylation at...
متن کاملBone mineral density loss in postmenopausal onset rheumatoid arthritis is not greater than premenopausal onset disease
Background: Postmenopausal onset rheumatoid arthritis (post-RA) is expected to have greater bone mineral density (BMD) loss than premenopauasal onset (pre-RA) due to estrogen deficiency and aging. This study aimed to compare the BMD status of the two RA groups with age-matched non-RA controls. Methods: The patients with RA on follow-up examination were stratified according to age of onset. ...
متن کاملBone mineral density loss in postmenopausal onset rheumatoid arthritis is not greater than premenopausal onset disease
Abstract Background: Postmenopausal onset rheumatoid arthritis (post-RA) is expected to have greater bone mineral density (BMD) loss than premenopauasal onset (pre-RA) due to estrogen deficiency and aging. This study aimed to compare the BMD status of the two RA groups with age-matched non-RA controls. Methods: The patients with RA on follow-up examination were stratified according to age...
متن کاملPsychiatric onset Alexander disease: an important challenge in neuropsychiatric diagnosis
Introduction: Alexander disease is a heterogenous group of diseases with various manifestations based on age of disease onset. This rare leukodystrophy syndrome with mutations in GFAP Gene could present with developmental delay and seizure in infantile form to ataxia and bulbar palsy in adulthood. However psychiatric symptoms are not well-defined and usually evaluate after disease diagnosis not...
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ژورنال
عنوان ژورنال: BMJ
سال: 1934
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.3827.841